I tend to look for charities that meet immediate needs, so local food banks are high up on the priority list.
If I have something to spare and see a land back fund or similar indigenous initiative that presently needs funding I often go that way. There’s a lot of indigenous folks doing critical environmental work here in the US so if I suddenly came into a ton of money I’d be able to move I’d probably look for a way to help whatever decentralized initiative might need it most urgently in that area.
Folks need material support to preserve their lives and lifeways my maternal ancestors contributed to wrecking, and we’re also all in a lot of trouble here environmentally and we need to back the expertise folks frequently bring to the table. Two separate but interrelated priorities. It just makes sense.
Probably one from https://Givewell.org - I’d try to pick a charity that would do the most measurable good with the donation.
I like GiveDirectly. It gives people resources in the most flexible possible form (cash) so that they can attend to their needs more efficiently than if they had to deal with contributions in more rigid forms. One downside is that this doesn’t directly address the oppressive institutions/policies that reproduce precarity and suffering, but it does give people a tiny bit more power within their lives while surviving under oppression